Non - canonical Decapentaplegic signaling activates Matrix 1 Metalloproteinase 1 to restrict Hedgehog activity and limit ectopic 2 eye differentiation in Drosophila 3 4
نویسندگان
چکیده
1 Non-canonical Decapentaplegic signaling activates Matrix 1 Metalloproteinase 1 to restrict Hedgehog activity and limit ectopic 2 eye differentiation in Drosophila 3 4 Poonam Aggarwal, Jayati Gera, Saikat Ghosh, Lolitika Mandal and Sudip 5 Mandal 6 7 8 9 10 * Molecular Cell and Developmental Biology Laboratory, Department of Biological 11 Sciences, Indian Institute of Science Education and Research Mohali, Punjab 140306, 12 India. 13 § Developmental Genetics Laboratory, Department of Biological Sciences, Indian 14 Institute of Science Education and Research Mohali, Punjab 140306, India. 15
منابع مشابه
The role of Wingless signaling in establishing the anteroposterior and dorsoventral axes of the eye disc.
The posteriorly expressed signaling molecules Hedgehog and Decapentaplegic drive photoreceptor differentiation in the Drosophila eye disc, while at the anterior lateral margins Wingless expression blocks ectopic differentiation. We show here that mutations in axin prevent photoreceptor differentiation and lead to tissue overgrowth and that both these effects are due to ectopic activation of the...
متن کاملDeciphering synergistic and redundant roles of Hedgehog, Decapentaplegic and Delta that drive the wave of differentiation in Drosophila eye development.
In Drosophila, a wave of differentiation progresses across the retinal field in response to signals from posterior cells. Hedgehog (Hh), Decapentaplegic (Dpp) and Notch (N) signaling all contribute. Clones of cells mutated for receptors and nuclear effectors of one, two or all three pathways were studied to define systematically the necessary and sufficient roles of each signal. Hh signaling al...
متن کاملThe morphogen Decapentaplegic employs a two-tier mechanism to activate target retinal determining genes during ectopic eye formation in Drosophila
Understanding the role of morphogen in activating its target genes, otherwise epigenetically repressed, during change in cell fate specification is a very fascinating yet relatively unexplored domain. Our in vivo loss-of-function genetic analyses reveal that specifically during ectopic eye formation, the morphogen Decapentaplegic (Dpp), in conjunction with the canonical signaling responsible fo...
متن کاملwingless inhibits morphogenetic furrow movement in the Drosophila eye disc.
Differentiation of the Drosophila eye imaginal disc is an asynchronous, repetitive process which proceeds across the disc from posterior to anterior. Its propagation correlates with the expression of decapentaplegic at the front of differentiation, in the morphogenetic furrow. Both differentiation and decapentaplegic expression are maintained by Hedgehog protein secreted by the differentiated c...
متن کاملcAMP-dependent protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in drosophila imaginal discs
Localized expression of decapentaplegic (dpp) is required for proper development of the Drosophila imaginal discs. Using genetic mosaics, we show that in the anterior compartment of appendage discs and anterior to the morphogenetic furrow in the eye disc, cells that lack cAMP-dependent protein kinase (PKA) activity ectopically express dpp. Pka- cells can influence the fate of neighboring cells ...
متن کامل